Stein D, Ovadia D, Katz S, Brar PC
The global incidence of HCC remains highly heterogeneous: Agestandardized incidence rates vary across regions, with the highest burden observed in East Asia and subSaharan Africa, and lower rates seen in many Western countries [2]
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Another regulator, TRIM21, binds to FSP1 through its PRY-SPRY domain and mediates K63 ubiquitination, facilitating FSP1 translocation to the plasma membrane
Additional kinases, such as cyclin-dependent kinase 4 (CDK4) and mitogen- and stress-activated kinases 1/2 (MSK1/2), contribute non-redundant regulatory roles: pharmacological inhibition of CDK4 attenuates eryptosis, while deficiency in MSK1/2 accelerates erythrocyte apoptotic turnover in vivo , emphasizing their importance in maintaining erythrocyte homeostasis (Lang et al., 2015a
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