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Interestingly, P2209L and A2224V were previously observed to enhance RF in gt1b but again in a more limited cell culture setup 56

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reported full-year worldwide revenue of about $65 billion in 2025, with Keytruda (pembrolizumab)/Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) sales amounting to roughly $31.7 billion and continuing to be the companys dominant growth engine, alongside contributions from pulmonary arterial hypertension (PAH) drug Winrevair (sotatercept-csrk), pneumonia vaccine Capvaxive (neumococcal 21-valent conjugate vaccine) and animal health products

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