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Although whether alpha-cell GLP-1 production and maturity state directly relate to alpha-cell proliferative state has yet to be established, these studies identify a range of alpha-cell maturity and proliferative capacity within islets and allude to the possibility that alpha-cell GLP-1 production may be inherently involved in this heterogeneity

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After changing the RBCs mechanical phenotype, their functional viability is impaired

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It is important to emphasise lifestyle support (i.e