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Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early weight-loss and metabolic data in Phase 2 trials, but it is not yet approved in the UK and carries notable side effects and safety uncertainties

Most side effects improve within 12 weeks

Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials

The indication, dose, insurance coverage, and medical appropriateness depend on the specific medication and patient

GLP-1 weight loss is up to 35% muscle mass loss GLP-1 weight loss can be 20% to 35% loss of lean tissue instead of fat

Industry analysts project a potential launch in 2028, though timelines could shift depending on regulatory review