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The immunological defects leading to the development of SLE are a product of two stages: first, systemic autoimmunity that induces serum autoantibodies and, second, immunological events that induce organ damage (6)

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A series of accessory genes, which encode accessory proteins (ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8b, ORF9b and ORF14), lie between these structural genes

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Any peptide that affects autonomic tone, cholinergic signaling, or adrenergic pathways