Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue
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When all three are activated, the body becomes more efficient with insulin and visceral fat can fall away
GLP-1 as a target for therapeutic intervention
Glucagon receptor activation has mixed cardiovascular effects, including some vasodilatory effects through cAMP signaling, balanced against the small heart rate increase The BP effects of retatrutide may include a small contribution from these direct mechanisms on top of the larger weight-loss-mediated effect
