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Comment: Several commenters expressed concern about replacing the estimated allowed amount with the median allowed amount and adding the 10th and 90th percentile allowed amounts so soon after the January 1, 2025 effective date of the estimated allowed amount requirement

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Its activity profile is best understood as systems-level polypharmacology rather than single-receptor agonism: published research has documented effects on nitric oxide system signalling, growth-factor receptor expression (including VEGF receptor 2 and growth-hormone receptor), dopamine and serotonin pathway markers, and angiogenic factor regulation

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