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GH Gut or Organ Growth (at supraphysiological doses) Prolonged high-dose GH use, especially in combination with insulin or anabolic steroids, has been linked to visceral organ growth and abdominal distension

Estradiol has been shown to impact this central CCK expression

For instance, in September 2025, Pfizer announced plans to acquire Metsera, entering into a definitive agreement

Synthetic HGH provides exogenous hormone that creates constant, non-pulsatile rise, can suppress natural GH production, needs careful dosing to avoid side effects, and is greatly more expensive