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However, the hepatic extraction ratio for morphine is morphine clearance (60 L/h/70 kg) divided by hepatic blood flow (90 L/h/70 kg) or 0.67

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In addition, VRK2 overexpression confers PC cells resistant to ferroptosis induced by exogenous ROS through promoting ER-to-Golgi trafficking of SLC7A11, which echoes the findings that PC cells with high expression of VRK2 have an elevated basal level of GSH