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The findings strongly added to the potential benefit of GLP-1RAs in reducing glaucoma risks

"Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase)." Journal of Affective Disorders, 2024

Thus, clinical trials are needed to establish the benefits/risk profile in HF, considering that no properly designed, HF-specific randomised clinical trials have been completed with GLP-1 RAs in any of the HF phenotypes

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While data from a RCT controls for many of the potential confounding factors, using data from non-primary endpoints requires caveats

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