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The biggest reasons for decreased glutathione levels include chronic stress, environmental toxins, GMO consumption, chronic disease, antibiotic overuse and even simple aging

doi:10.1016/j.rbmo.2018.09.016

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Aqua/Water/Eau, Glycerin, Peg-6 Caprylic/Capric Glycerides, Disodium Edta, Mannitol, Xylitol, Cetrimonium Bromide, Rhamnose, Niacinamide, Hexyldecanol, Sodium Hydroxide, Pyrus Malus (Apple) Seed Extract, Brassica Campestris (Rapeseed) Sterols, Tocopherol, Fragrance (Parfum)

One article proposed that excessive serotonin levels could explain classic symptoms of ME/CFS (433), as it would promote the release of excess CRH, and therefore cause chronic reactivation of the HPA axis (434)