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Sections (5 mm) were stained with Safranin-O/Fast Green and hematoxylin and eosin

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The deficiency or mutation of Kelch-like ECH-associated protein 1 (KEAP1), mediated by p62, leads to the activation and upregulation of Nrf2

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In addition, alterations in reproductive hormone levelsincluding decreased testosterone and increased LH/FSH ratioshave been documented in diabetic men, further supporting the endocrine disruption described in experimental studies [164, 302]