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: #ObesityCare #GLP1 #Enobosarm #BodyComposition #LeanMassPreservation #ClinicalTrials #BiotechNews #MetabolicHealth #SARM #WeightManagement #HealthTech #Veru #PrecisionMedicine #DEXA #FunctionalOutcomes Harry Fisch MD Mitchell Steiner, MD, FACS, To view or add a comment, sign in 2025 Exercise Evidence Colleagues, new Endocrine Reviews article on exercise + obesity DATA ALIGNS #ADASOC2026: 150 min/week validated - confirms 20% insulin sensitivity, 0.8% HbA1c #AHA/ACC: Exercise for CVD risk - confirmed across all intensities #AASLD:Exercise first-line for MASLD - validated in just 2 weeks EVIDENCE AHEAD OF GUIDELINES: GLP-1 RA + exercise:60% less regain Bariatric surgery protocols: 5-year pre/post-op data Benefits independent of weight loss:Underemphasized in current standards KEY DATA - COMBINATION THERAPY: GLP-1 RAs + Exercise: Liraglutide + vigorous exercise 4x/week: - 9.5kg loss at 1 year - Only 2.5kg regain vs
The blockbuster weight loss medications that have transformed conversations about obesity and metabolic healthsemaglutide (Ozempic and Wegovy), tirzepatide (Zepbound or Mounjaro), and retatrutide (a newcomer on the block thats not yet FDA approved but highly anticipated for approval next year)are all peptide-based drugs
With delayed gastric emptying, food is still actively sitting in your stomach when you lie down, which increases reflux and nausea
[DOI] [PubMed] [Google Scholar] 12.Kolovrat M., Gojkovic S., Krezic I., Malekinusic D., Vrdoljak B., Kasnik Kovac K., Kralj T., Drmic D., Barisic I., Horvat Pavlov K., et al
While it isnt a mass-building peptide like MK-677, Tesamorelin shines in cutting phases, recomposition, and longevity-based protocols thanks to its ability to restore GH signaling without spiking hunger or blood glucose
