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However, we do recommend all patients consider taking a break at 6 months for at least one month off

* **Hypersensitivity to Hydroxyzine or Related Compounds:** Individuals with known allergic reactions to hydroxyzine, cetirizine, or other piperazine derivatives must avoid its use due to the risk of cross-reactivity leading to rash, bronchospasm, or anaphylaxis

Finally, recent clinical trials for obesity are exploring very high doses of semaglutide, with regimens of up to 50 mg/week demonstrating additional efficacy 8688

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