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Tirzepatide is a 39-amino-acid peptide with a fatty acid sidechain (a C20 icosanoyl moiety) that makes it sensitive to agitation-induced aggregation

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

Physical activity boosts calorie burn and supports muscle health during weight loss