The general principle of escalation observed in the trial involved starting at a low dose and titrating upward at approximately four-weekly intervals, with the highest-dose arm targeting 12 mg once weekly
If more than 3 days have passed, skip that dose and resume your regular schedule
Cardiovascular and kidney effects trend net positive over multi-year follow-up
Based on similar medications like Zepbound, if you miss a dose, you may be instructed to take it as soon as possible within 4 days
doi:10.4093/dmj.2025.0242 3
Takaaki Kanemaru (Department of Morphology Core Unit, Kyushu University Hospital) and The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences, which is partially supported by the Mitsuaki Shiraishi Fund for Basic Medical Research