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A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma

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This allows the physician to check for any problems such as ulcers, tumors, or bleeding in the stomach area

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The treatment uses microneedles to prick the skin and create microchannels