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This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover
Interestingly, strains from these genera often converge at the functional level in terms of production of short-chain fatty acids (SCFAs), such as propionate, acetate and butyrate that may exert anti-inflammatory effects [184]
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