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240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

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PMID 2052056

This varies by surgery type, commute, anaesthesia recovery, and patient comfort