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ChREBP mediates carbohydrate, but not fat-induced DNL as high fat diets do not activate ChREBP and may even decrease ChREBP activity [43, 47]

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This iron regulates several proteins involved in iron homeostasis at the translational level via the Fe/IRP/IRE system (Muckenthaler et al., 2008), including TfR1, which is downregulated when intracellular iron levels increase (Sung et al., 2000)