Reduced GSH availability, whether due to metabolic dysregulation or chronic ROS exposure impairs the redox buffering capacity of immune cells
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The reduced form of glutathione (GSH) reacts with hydroxyl radicals, peroxyl radicals, superoxide, and other harmful oxidants
This process uses the GGT1 enzyme.[ref][ref] Enzyme reactions involving glutathione: Glutathione peroxidase (GPX1 gene, below) is an important enzyme that utilizes glutathione in antioxidant reactions, such as in neutralizing hydrogen peroxide and lipid peroxide
The two routes use fundamentally different dosing logic, and mixing them produces incorrect protocols
Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance