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At the late stage, increased lipophagy releases PUFAs that serve as substrates for lipid peroxidation, whereas the knockdown of RAB7A or PGRMC1 inhibits lipophagy-induced ferroptosis [210, 211]

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Importantly, the obesity drugs reduced food intake even when the aversion pathway was inhibited

Antioxidant supplementation can remove excess reactive oxygen species, reduce inflammation, and stabilize the oxidative-reductive environment, thereby improving skeletal muscle blood flow and oxygen utilization capacity, the researchers wrote in the study summary

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