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The primary mechanism involves enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it stimulates insulin release only when blood sugar levels are elevated
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Expert Opin Ther Targets (2008) 12(10):126574.10.1517/14728222.12.10.1265 40 GaoCHlscherCLiuYLiL
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Notably, pDCs are the major producers of IFN- in SLE, and IFN- production from pDC mediated by TLR9 is reduced by mTOR inhibitor, which regulates pDC differentiation and activation by modulating mitochondrial biogenesis and energy metabolism (78)
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