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We used the Preacher and Hayes bootstrapping method, as implemented in the mediation (v4.5.0) R package 75 , using general linear models with sex and country of recruitment as covariates

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Interestingly, TDP-43 proteopathy is exacerbated in the presence of optineurin (OPTN) mutations, the genetic factor responsible for such accumulation (Thakur et al

10.1016/j.gene.2020.144969 171 ZhangH.ZhouF.WangY.XieH.LuoS.MengL.et al (2020b)