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J Dent Res (2009) 88(9):8515

Respiratory Symptoms: Histamine causes bronchoconstriction narrowing of the airways through H1 receptor activation in bronchial smooth muscle

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Pro-inflammatory phenotypic macrophages subsequently promote VSMC calcification by stimulating carbonic anhydrase I (CA1) and CA2 via secreting TNF, or NLRP3 inflammasome