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These effects are likely primarily mediated through actions in various regions of the brain involved in the regulation of appetite and food intake [18], as supported by preclinical studies [19,20,21,22], multiple human imaging studies [18], and the GLP-1R expression patterns in the human brain [9, 23]

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It has been shown that liraglutide promotes natriuresis by atrial natriuretic peptide (ANP) secretion from cardiomyocytes in an Epac2-depdenent manner ( Fibrosis GLP-1RAs have been shown to attenuate renal fibrosis

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However, some studies are exploring their potential benefits in this population, but they are not currently recommended

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Semaglutide : FDA-approved since 2017 for T2D, 2021 for obesity

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