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These include appetite control, insulin sensitivity, fat oxidation, and overall energy expenditure

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Alternative approaches to consider Before committing to an untested combination, researchers should consider whether simpler approaches might achieve similar goals with known safety profiles

TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice

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24,25 The mechanisms of regulation and synthesis for GLP-1secretion are summarized in Figure 1