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Mechanism: Modulates inflammatory signaling pathways and reduces oxidative stress

Voltage-dependent anion channels (VDAC) are a transmembrane pathway found in the cell membrane and mitochondria

The survival rate of S-3/pKLH167, S-3/pKLH337, S-3/pKLH341, and S-3/pKLH344 were 73, 90, 83, and 81%, respectively, which were higher than that of wild-type (55%) under 3.5 mmol/L H 2 O 2 (Figure 4C)

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Four isoforms of human glutaminase are divided into two highly active renal glutaminase types encoded by GLS1 and two low active hepatic glutaminase types encoded by GLS2