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Cu(II) bound to HSA constitutes approximately 25% from total blood copper (on average 4.2 M) and this copper pool could also be in equilibrium with Cu(II) ions bound to free amino acids, primarily His

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The lipid modification at the Cagri N-terminus is poorly resolved in the cryo-EM maps for AMYR complexes, but some limited density was visible for the Glu linker and a very short segment of the acyl chain in the AMY 1 R complex (Fig

Moreover, it is closely correlated to impaired levels of blood thiamine diphosphate (TDP), a crucial coenzyme of pyruvate dehydrogenase and -ketoglutarate dehydrogenase (KGDHC) enzymes allocated in the Krebs cycle (Sang et al., 2018)