The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible
Although some preliminary reports suggest that NAC may be beneficial in treating these conditions, many of the studies involved small groups of patients who took variable doses of NAC, and because of this, the study results are not generalizable to the population as a whole
Endocrine 59 (2), 383394
Bella, F
Gerster H: The importance of vitamin-B6 for development of the infant: human medical and animal experimentation studies
BCBS Massachusetts, BCBS Michigan, BCBS Vermont, Independence Blue Cross in Pennsylvania, Blue Cross of Idaho, and Highmark (which operates across Pennsylvania, West Virginia, New York, and Delaware) all implemented restrictions