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1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies

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If no improvement after proper evaluation, discuss alternative approaches with your physician

Author contributions LS: Data curation, Formal analysis, Visualization, Writing original draft

The primary reviewers were not blinded to the authors, institutions or source of publication at any time during the selection process

The mean change from baseline and across sessions in success rate in achieving rewards through effort exertion was used to evaluate changes in objective motivation