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The Vegan Society website states: To get the full benefit of a vegan diet, vegans should do one of the following: eat fortified foods two or three times a day to get at least three micrograms (mcg or g) of B12 a day, OR take one B12 supplement daily providing at least 10 micrograms, OR take a weekly B12 supplement providing at least 2000 micrograms

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The interaction very rarely results in a pernicious anemia that appears reversible with discontinuation of metformin or with Methylcobalamin, vitamin B12 supplementation

In some cases, vitamin B12 and folate deficiencies may occur together

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