Doses of folic acid greater than 0.1 mg per day may result in hematologic remission in patients with vitamin B 12 deficiency
A study reported that berberine facilitates GLP-1 production by activating the -catenin/TCF4 signalling pathway and via miR-106b downregulation 3
A third major risk is dosing
Minimal Transfer to Breast Milk : Studies show that taking glutathione supplements is unlikely to significantly alter the composition of breast milk, meaning that breastfeeding mothers can consume it without worrying about adverse effects on their milk supply or quality
Annu Rev Pharmacol Toxicol 47:14383, PMID: 17029566 Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N (2010) Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload
These effects are most common during initial dosing and dose increases