A summary of the main factors influencing GLP-1 secretion is shown in the image below (Huber et al, 2024)
Freezing the reconstituted solution is also an option for longer-term storage, but this comes with its own set of rulesnamely, avoiding repeated freeze-thaw cycles which can fracture the peptide structure
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J Pajoohandeh 15:16 Koushik B, Rajen D, Debanjana S, Nimisha P, Asim KB, Mohuya PP, Nandini Sh, Gargi RC, Aniruddha B, Rajkumar M, Krishnendu A, Prity C, Prithviraj K, Alak KS (2022) Polycystic ovary syndrome and its management: in view of oxidative stress
These findings suggest that future therapeutic strategies may focus on enhancing the nerve-bone communication pathway rather than administering CGRP directly
Funding This work was supported by the National Key Research & Developmental Program of China (2022YFC2702600), and the special fund of the National Clinical Key Specialty Construction Program, P