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We compared the single agonist SEMA to the triple agonist RETA in DIO models and report that RETA potently improved cancer outcomes and revealed immune reprogramming as a potential underlying mechanism

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, et al

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when compounded as an intranasal spray, it may bypass the blood-brain barrier via olfactory and trigeminal pathways, producing central concentrations that cannot be achieved with peripheral dosing

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(2021) 374:n1448