However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food
Refer to the DEFENCATH Prescribing Information for all of the approved conditions of use of this drug (e.g., indication(s), population(s), dosing regimen(s), safety information)
It is not a toxicity concern but an efficacy consideration
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But B12 is involved in complex body wide set of interactions
The methylcobalamin component may partially offset some GI side effects