[5, 6] It is considered the main redox buffer in human cells owing to its large amount of reducing equivalents, [7] and is an important enzyme cofactor that serves as a neuromodulator in the central nervous system
In mammalian models, exposure has been reported as concentrations in drinking water (e.g., 0.550 g/mL for 90 days) [134] and as oral doses spanning from mg/kg/day regimens to very high bolus doses (e.g., up to 2000 mg/kg by gavage) [141]
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