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The area under the concentration curve obtained when administered at the same dose, corresponds approximately to twice that obtained when it is applied by oral or rectal route, as the active principle is metabolized almost 50% during its first passage through the liver (first pass effect), when administered by the routes mentioned

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These diminished SCFAs lead to increased intestinal permeability, facilitating translocation of bacterial endotoxins into systemic circulation, which further exacerbates inflammation and metabolic dysregulation ( Table 1 ) [89, 90]

dispose of the needle properly Injection sites should be rotated to prevent lipodystrophy

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