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While both promote angiogenesis and tissue repair, they do so through distinct molecular pathways: BPC-157 primarily modulates the nitric oxide system and upregulates vascular growth factor receptors, whereas TB-500 operates through actin cytoskeleton regulation and endothelial cell migration

PubMed Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS (2011)

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The theoretical concern about angiogenesis-driven tumor promotion persists despite absence of evidence specifically because the question has not been adequately studied in humans over meaningful timeframes