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Indications Routine immunization (children & adults) Booster doses Wound management (injury with risk of tetanus) During pregnancy (to prevent neonatal tetanus) Immunization Schedule In Children Given as part of: DTaP / Pentavalent vaccine In Adults Booster every 10 years In Pregnancy 2 doses during pregnancy (if not previously immunized) Dose & Route 0.5 mL Intramuscular (IM) injection Usually in deltoid muscle (adults) Side Effects Common: Pain at injection site Redness Mild swelling Low-grade fever Rare: Severe allergic reaction (anaphylaxis) Neurological reactions (very rare) Wound Management If a patient comes with a deep wound: Doctor evaluates: Immunization history Type of wound If vaccination incomplete Tetanus toxoid + Tetanus immunoglobulin may be given

Adverse reactions for the 1.28 mg dose (11.6 mg/vial formulation) of EGRIFTA WR are expected to be similar to those observed with the 2 mg dose (1 mg/vial formulation) of EGRIFTA [see CLINICAL PHARMACOLOGY ]