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In the SURMOUNT-1 trial, tirzepatide achieved up to 22.5% body weight reduction over 72 weeks, compared to roughly 17% with semaglutide in similar studies

Cardioembolic strokes, most frequently caused by atrial fibrillation (AF), are associated with worse outcomes, and a higher risk of hemorrhagic transformation (HT) compared with ischemic strokes from other causes (144146)

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