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It does not mean drug is dangerous for everyone

These condensates create privileged microenvironments for the localized activation of PKA, restricting its activity to the mitochondrial vicinity to ensure phosphorylation of specific targets such as MIC19 (Zhang et al., 2020)

While they do not directly interfere at a metabolic level, combining them may amplify gastrointestinal effects in sensitive individuals

For this reason, these medications are often used in people with type 2 diabetes who also have heart or kidney problems

Safety of GLP-1RA plus SGLT2i combination therapy GLP-1RAs and SGLT2is are both generally well-tolerated when used individually, with a minimal risk of hypoglycemia, unless used in combination with insulin or insulin secretagogues [4, 9]

Nature Medicine 30(11):3261-3271, 2024