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Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in systemic lupus erythematosus

KEAP1/NRF2 mutant cells are protected against cysteine-starvation induced ferroptosis due to elevated GCLC expression and limited glutamate accumulation, and dual targeting of cystine import and GCLC activity can overcome the resistance of NRF2 active cells to ferroptosis (Kang et al., Cell Metab 2021)

in contrast, knocking out LPCAT3 does not confer robust protection against ferroptosis, suggesting that these family members may have compensatory mechanisms [41]

Tirzepatide, a dual GIP/GLP-1 receptor agonist, slows gastric emptying and modulates insulin secretion through incretin hormone pathways

Cancer 18 , 619633 (2018)

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