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MolProbity 4.5 as a part of the Phenix validation tools was used for model validation (Table 1)
When no applicable USP or NF drug-substance monograph exists and the substance is not a component of an FDA-approved drug, the 503A Bulks List is the relevant pathway
For that reason, the ER stores only 0.51% of the cells total cholesterol (Lange et al., 1999), comprising 35% of all ER lipids (Radhakrishnan et al., 2008)
Adding a schedule compression on top of a dose increase doubles the adaptation burden
doi: 10.1186/s13287-020-01689-5 142 WuAYPeeblesRS
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