This doesnt mean youll be constantly nauseous for 8 weeks straight, but rather that when a bout of nausea hits, it typically resolves within a week or so
The 12mg maximum is lower than tirzepatide but achieves greater efficacy, demonstrating that three receptor targets provide synergistic effects beyond what raw dosing would suggest
The real key is going to be side effects over time, if retatrutide is like other drugs in the class then the side effects should decrease with time, but unfortunately, we dont have that today, at this point I have some questions and minor concerns but without the data over time its hard to speculate about tolerability further beyond saying its similar to other drugs in the class
Troubleshooting common issues on Fella or any GLP-1 program Not every weight loss journey is linear
Diabetes Care (2018) 41(9):192637
Sibutramine (Meridia) was removed after it was linked to heart attack and stroke in people at highest risk for them