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For this reason, our 2001 B12 recommendations in What Every Vegan Should Know about Vitamin B12 were focused as much on keeping homocysteine levels low as on preventing the traditional B12 deficiency symptoms of blood and nerve abnormalities

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Protocols using doses below 0.5mg daily may require 1620 weeks to demonstrate observable improvement

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doi: 10.1016/0196-9781(94)90152-x

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