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Nat Rev Endocrinol 2012;8:728-42

Metformin contains no GLP-1 activity whatsoever, making it fundamentally different from modern peptide-based therapies that directly target appetite centers in the hypothalamus

In some cases, doctors may recommend high doses more than 1,000 micrograms (mcg) per day

Zhang for their insightful suggestions and meticulous revisions during the review process

Deficiency can lead to fatigue, cognitive impairment, muscle weakness, and other symptoms, making timely diagnosis and treatment critical for overall health

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