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This dual-action difference explains why some patients respond better to tirzepatide than semaglutide

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Although this new agent (cagrilintide/semaglutide) has not been addressed from a kidney perspective in clinical studies, it is known that amylin binds to G proteincoupled receptors in kidney and has been reported to influence proximal tubular sodium transport and activate the RAAS (83, 84)

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