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Di Bartolomeo et al

Rocca C, Bartolo AD, Granieri MC, Rago V, Amelio D, Falbo F, Malivindi R, Mazza R, Cerra MC, Boukhzar L, Lefranc B, Leprince J, Anouar Y, Angelone T (2022) The antioxidant selenoprotein T mimetic, PSELT, induces preconditioning-like myocardial protection by relieving endoplasmic-reticulum stress

Studies have uncovered differentially methylated profiles in paternal sperm DNA that is linked with the risk of ASD at birth [102], and the usage of a psychoactive agent, which is also associated with the risk of ASD at birth, can alter DNA methylation patterns on maternally imprinted and ASD candidate genes in the sperm [103]

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However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs