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The delivery method (IV vs

This changes the in vivo distribution of the nanoparticle carriers, induces inflammatory responses, disrupts the stability of the formulation, and even triggers hypersensitivity reactions [217]

Enterohepatic circulation further influences LT4 metabolism, with conjugation via glucuronidation and sulfation in the liver, secretion into bile, and partial reabsorption by the intestinal flora (Eghtedari And Correa 2023)

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However, it is currently unclear and to what extent the differences observed in CVOT reflect the heterogeneous pharmacological properties of each drug in the GLP-1RA category